Giving you an extra layer of support with Makena Care Connection®

When you start Makena® (hydroxyprogesterone caproate injection), you get more than the medicine. You get personalized resources that are specifically designed to help you throughout your experience with Makena. Think of us as an extra layer of support.

Prescription Support

Helps you get your prescription approved in a timely manner

You’re unique and so are your insurance benefits. Because getting your medicine in a timely manner is important, we’re here to lend a hand. We have a dedicated team who understands the coverage policies for Makena. Our experts can handle the details between your healthcare professional, insurance company, and pharmacy so you receive your Makena when you need it.

"It was really helpful to me that the nurse and the representative of the Makena Care Connection determined what issues I was facing and what my next steps were. It was one less thing for me to worry about."


Financial Assistance

Helps ensure affordable access to Makena

We believe that you should be able to focus on your pregnancy more than the cost of your medication. To support that, AMAG Pharmaceuticals is committed to making sure that moms like you have affordable access to Makena. We offer eligible patients* financial assistance.

Commercially insured moms whose health plan covers Makena

We help lower out-of-pocket costs associated with copays, coinsurance, and deductibles.*

Uninsured and commercially underinsured moms

We provide a free course of therapy.

*Each patient’s eligibility is evaluated on an individual basis. To be eligible, patients must meet the FDA-approved indication (pregnant with a single baby with a history of singleton spontaneous preterm birth <37 weeks).1 In compliance with federal regulations, patients insured by a government-funded program (e.g., Medicaid, TRICARE, etc.) are not eligible. There are no upper-level income caps.

"Thanks to the financial assistance I received, I had an affordable copay, which made such a difference for my family."


Home Injections by Healthcare Professionals

Provides injection administration in the comfort of your home*

We can help coordinate Makena injections through a home healthcare organization. Once you’re approved by insurance, you can choose to receive your injections by a healthcare professional in the comfort of your home or another location that’s convenient for you.

Education & Adherence

Provides support that helps keep you on track with weekly injections

We understand that moms receiving Makena injections may need some encouragement and support to stick to their weekly injection schedule, and we want to help. This free service offers educational and adherence support to encourage you to make Makena part of your pregnancy and take an active role in your health.

A level of personalized support you can expect:

  • Injection reminders that support weekly treatment
  • Educational materials to address topics during pregnancy
  • Encouragement so you can take an active role in your health

"Knowing she was just a phone call away gave me peace of mind. I appreciated feeling like I had someone supporting me every step of the way."


*If approved by your insurance.

Have Questions? Connect with us.

1-800-847-3418 • 8 am–8 pm ET •

Makena Care Connection® offers personalized support

Deb, a nurse practitioner, explains the benefits of choosing Makena® (hydroxyprogesterone caproate injection) for reducing preterm birth and how the support provided by Makena Care Connection can help with the prescription process, financial assistance, home injections, and sticking to your treatment.

Get help paying for Makena

We believe patients should be able to focus on their pregnancy more than the cost of their medication. To support that, AMAG Pharmaceuticals is committed to ensuring affordable access to Makena. We proactively screen and offer eligible patients* financial assistance with no upper-level income caps.

*Each patient’s eligibility is evaluated on an individual basis. To be eligible, patients must meet the FDA-approved indication (pregnant with a single baby with a history of singleton spontaneous preterm birth). In compliance with federal regulations, patients insured by a government-funded program (eg. Medicaid, TRICARE, etc.) are not eligible.

Makena patient testimonial

Makena (hydroxyprogesterone caproate injection) is a prescription hormone medicine (progestin) used to lower the risk of preterm birth in women who are pregnant with one baby and who have delivered one baby too early (preterm) in the past. Makena was shown to work based on a lower number of women who delivered babies at less than 37 weeks of pregnancy. There are no studies showing Makena reduces the number of babies who have serious problems shortly after birth or who die. It is not known whether Makena is safe and effective in women who have other risk factors for preterm birth.

Important Safety Information for Makena (hydroxyprogesterone caproate injection)

Makena should not be used in women with any of the following conditions: blood clots or other blood clotting problems, breast cancer or other hormone-sensitive cancers, or history of these conditions; unusual vaginal bleeding not related to your current pregnancy, yellowing of the skin due to liver problems during pregnancy, liver problems, including liver tumors, or uncontrolled high blood pressure.

Before you receive Makena, tell your healthcare provider if you have an allergy to hydroxyprogesterone caproate, castor oil, or any of the other ingredients in Makena; diabetes or prediabetes, epilepsy, migraine headaches, asthma, heart problems, kidney problems, depression, or high blood pressure.

In a clinical study, certain complications or events associated with pregnancy occurred more often in women who received Makena. These included miscarriage (pregnancy loss before 20 weeks of pregnancy), stillbirth (fetal death occurring during or after the 20th week of pregnancy), hospital admission for preterm labor, preeclampsia (high blood pressure and too much protein in your urine), gestational hypertension (high blood pressure caused by pregnancy), gestational diabetes, and oligohydramnios (low amniotic fluid levels).

Makena may cause serious side effects including blood clots, allergic reactions, depression, and yellowing of your skin and the whites of your eyes. Call your healthcare provider right away if you think you have symptoms of a blood clot (leg swelling, redness in your leg, a spot on your leg that is warm to touch, or leg pain that worsens when you bend your foot) or symptoms of an allergic reaction (hives, itching, or swelling of the face). The most common side effects of Makena include injection site reactions (pain, swelling, itching, bruising, or a hard bump), hives, itching, nausea, and diarrhea.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit or call 1-800-FDA-1088.

Please see full Prescribing Information for Makena.

Reference: 1. Makena® (hydroxyprogesterone caproate injection) prescribing information, AMAG Pharmaceuticals, 2016.

Important Safety Information and Indication

If you are enrolled in the Makena Care Connection or My Adherence Program, please note that our contact information has changed. If you have questions or would like to get in touch, please contact us at 1-800-847-3418, or write to us at