Reducing Risk with Makena®
Makena helps you get closer to term
What is Makena?
Makena, pronounced Ma-keen-a, is a hormone medicine (progestin) prescribed to lower the risk of having another preterm baby in women who are pregnant with one baby, and who’ve unexpectedly delivered one baby too early (before 37 weeks) in the past.6
Makena is a weekly injection (given every 7 days) by your healthcare provider either at their office or in your home.6
You can start Makena between 16 weeks and 20 weeks, 6 days of your pregnancy, depending on your healthcare provider’s direction.6
Is Makena right for you?
In a clinical study, taking Makena significantly lowered the rate of preterm birth compared to moms who did not take Makena.6
If you answer “yes” to all of the questions below, talk with your healthcare provider to see if Makena could help you reduce your risk of another preterm birth.5
- Have you unexpectedly delivered a baby preterm (less than 37 weeks gestation, or more than 3 weeks too early) before?
- Was your preterm birth due to preterm labor or your water breaking?
- Are you currently pregnant with one baby?
While there are many causes for preterm birth, the safety and benefits of Makena have been demonstrated only in women who’ve unexpectedly delivered their baby prior to 37 weeks of pregnancy. Makena is not meant for use in women with multiple gestations or other risk factors for preterm birth.6
Start the conversation with your healthcare provider with this useful guide >
Makena administration options
- Designed so you never see the needle
- Given in the back of the upper arm under the surface of the skin with a shorter, thinner needle
- Full dose delivered in about 15 seconds
- Given into your hip (upper outer area of your buttocks) into the muscle with a longer needle
- Full dose delivered over the course of one minute or longer
Makena therapy schedule
Makena is an injection given by a healthcare provider6:
- In the healthcare provider’s office, or
- At home during a home healthcare visit (if covered by your insurance)
With both Makena injection options, therapy starts between 16 weeks and 20 weeks, 6 days of your pregnancy, depending on your healthcare provider’s direction. You will receive 1 injection each week (every 7 days) until week 37 (your last injection could be as late as 36 weeks, 6 days) or until you deliver your baby, whichever happens first.6
Home injections by healthcare professionals
Weekly injections of Makena may be administered in your home by a trained healthcare professional, if approved by your insurance plan. Find out more >
Is Makena safe?
You and your healthcare provider should consider the benefits and risks of therapy with Makena prior to deciding if Makena is right for you.
Makena should not be used if you6:
- Have now or have had a history of blood clots or other blood clotting problems
- Have now or have had a history of breast cancer or other hormone-sensitive cancers
- Have unusual vaginal bleeding not related to your current pregnancy
- Have yellowing of skin due to liver problems during your pregnancy
- Have liver problems, including liver tumors
- Have uncontrolled high blood pressure
Before you receive Makena, tell your healthcare provider if you6:
- Have an allergy to hydroxyprogesterone caproate, castor oil, or any of the other ingredients in Makena
- Have diabetes or prediabetes
- Have epilepsy
- Have migraine headaches
- Have asthma
- Have heart problems
- Have kidney problems
- Have depression
- Have high blood pressure
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
What are the possible side effects?
For moms: Makena may cause serious side effects, including6:
- Blood clots—Symptoms of a blood clot may include leg swelling, redness in your leg, a spot on your leg that is warm to the touch, or leg pain that worsens when you bend your foot
- Allergic reactions—Symptoms of an allergic reaction may include hives, itching, or swelling of the face
- Yellowing of your skin and the whites of your eyes
The most common adverse reactions observed with Makena were injection site pain (pain, swelling, itching, bruising, or a hard bump), hives, itching, nausea, and diarrhea.6
In a clinical study, certain complications or events associated with pregnancy occurred more often in women who received Makena. These included miscarriage (pregnancy loss before 20 weeks of pregnancy), stillbirth (fetal death occurring during or after the 20th week of pregnancy), hospital admission for preterm labor, preeclampsia (high blood pressure and too much protein in your urine), gestational hypertension (high blood pressure caused by pregnancy), gestational diabetes, and oligohydramnios (low amniotic fluid levels).6
For babies: In a follow-up study, children between the ages of 2 and 5 years old were evaluated for development in various physical, mental, and social measures. The results were comparable to children born to non-Makena-treated moms.7